Dual Inhibition of Autophagy and PI3K/AKT/MTOR Pathway as a Therapeutic Strategy in Head and Neck Squamous Cell Carcinoma

Dual Inhibition of Autophagy and PI3K/AKT/MTOR Pathway as a Therapeutic Strategy in Head and Neck Squamous Cell Carcinoma

Genomic analyses of head and neck squamous cell carcinoma (HNSCC) have highlighted alterations in the phosphatidylinositol 3-kinase (PI3K) signaling pathway, presenting a therapeutic target for multiple ongoing clinical trials with PI3K or PI3K/MTOR inhibitors. However, these inhibitors can potentia...

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Bibliographic Details
Main Authors: Monique Bernard, Guillaume B. Cardin, Maxime Cahuzac, Tareck Ayad, Eric Bissada, Louis Guertin, Houda Bahig, Phuc Felix Nguyen-Tan, Edith Filion, Olivier Ballivy, Denis Soulieres, Francis Rodier, Apostolos Christopoulos
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
autophagy
buparlisib
cancer
combination therapy
chloroquine
HNSCC
Online Access:https://www.mdpi.com/2072-6694/12/9/2371

Internet

https://www.mdpi.com/2072-6694/12/9/2371

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