Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma

Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma

Growth hormone (GH) facilitates therapy resistance in the cancers of breast, colon, endometrium, and melanoma. The GH-stimulated pathways responsible for this resistance were identified as suppression of apoptosis, induction of epithelial-to-mesenchymal transition (EMT), and upregulated drug efflux...

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Bibliographic Details
Main Authors: Reetobrata Basu, Prateek Kulkarni, Yanrong Qian, Christopher Walsh, Pranay Arora, Emily Davis, Silvana Duran-Ortiz, Kevin Funk, Diego Ibarra, Colin Kruse, Samuel Mathes, Todd McHugh, Alison Brittain, Darlene E. Berryman, Edward O. List, Shigeru Okada, John J. Kopchick
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
growth hormone receptor (GHR)
growth hormone (GH)
melanoma
JAK
STAT
SRC (sarcoma or c-Src)
chemoresistance
MITF
Online Access:https://www.mdpi.com/2072-6694/11/9/1352

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https://www.mdpi.com/2072-6694/11/9/1352

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