Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma
Growth hormone (GH) facilitates therapy resistance in the cancers of breast, colon, endometrium, and melanoma. The GH-stimulated pathways responsible for this resistance were identified as suppression of apoptosis, induction of epithelial-to-mesenchymal transition (EMT), and upregulated drug efflux...
Main Authors: | Reetobrata Basu, Prateek Kulkarni, Yanrong Qian, Christopher Walsh, Pranay Arora, Emily Davis, Silvana Duran-Ortiz, Kevin Funk, Diego Ibarra, Colin Kruse, Samuel Mathes, Todd McHugh, Alison Brittain, Darlene E. Berryman, Edward O. List, Shigeru Okada, John J. Kopchick |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-09-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/11/9/1352 |
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