The DNA/RNA-dependent RNA polymerase QDE-1 generates aberrant RNA and dsRNA for RNAi in a process requiring replication protein A and a DNA helicase.

The DNA/RNA-dependent RNA polymerase QDE-1 generates aberrant RNA and dsRNA for RNAi in a process requiring replication protein A and a DNA helicase.

The production of aberrant RNA (aRNA) is the initial step in several RNAi pathways. How aRNA is produced and specifically recognized by RNA-dependent RNA polymerases (RdRPs) to generate double-stranded RNA (dsRNA) is not clear. We previously showed that in the filamentous fungus Neurospora, the RdRP...

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Bibliographic Details
Main Authors: Heng-Chi Lee, Antti P Aalto, Qiuying Yang, Shwu-Shin Chang, Guocun Huang, Daniel Fisher, Joonseok Cha, Minna M Poranen, Dennis H Bamford, Yi Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2950127?pdf=render

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http://europepmc.org/articles/PMC2950127?pdf=render

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