UP256 Inhibits Hyperpigmentation by Tyrosinase Expression/Dendrite Formation via Rho-Dependent Signaling and by Primary Cilium Formation in Melanocytes

UP256 Inhibits Hyperpigmentation by Tyrosinase Expression/Dendrite Formation via Rho-Dependent Signaling and by Primary Cilium Formation in Melanocytes

Skin hyperpigmentation is generally characterized by increased synthesis and deposition of melanin in the skin. UP256, containing bakuchiol, is a well-known medication for acne vulgaris. Acne sometimes leaves dark spots on the skin, and we hypothesized that UP256 may be effective against hyperpigmen...

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Bibliographic Details
Main Authors: Min Cheol Kang, Jae-Wook Lee, Taek Hwan Lee, Lalita Subedi, Hussain M. Wahedi, Seon-Gil Do, Eunju Shin, Eun-Yi Moon, Sun Yeou Kim
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
UP256
hyperpigmentation
tyrosinase
dendrite
ciliogenesis
melanogenesis
Online Access:https://www.mdpi.com/1422-0067/21/15/5341

Internet

https://www.mdpi.com/1422-0067/21/15/5341

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