Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates

A novel series of diethyl {4-[(5-substituted-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates designed as analogues of amonafide was synthesized. All phosphonates were assessed for antiviral activity against a broad range of DNA and RNA viruses and several...

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Bibliographic Details
Main Authors: Iwona E. Głowacka, Rafał Gulej, Piotr Grzonkowski, Graciela Andrei, Dominique Schols, Robert Snoeck, Dorota G. Piotrowska
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/21/11/1420