Comprehensive analysis of normal adjacent to tumor transcriptomes

Comprehensive analysis of normal adjacent to tumor transcriptomes

Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour...

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Main Authors: Dvir Aran, Roman Camarda, Justin Odegaard, Hyojung Paik, Boris Oskotsky, Gregor Krings, Andrei Goga, Marina Sirota, Atul J. Butte
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01027-z
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spelling doaj-92442fbf71dc46038ab5ef9c6bf555db2021-05-11T07:21:26ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-01027-zComprehensive analysis of normal adjacent to tumor transcriptomesDvir Aran0Roman Camarda1Justin Odegaard2Hyojung Paik3Boris Oskotsky4Gregor Krings5Andrei Goga6Marina Sirota7Atul J. Butte8Institute for Computational Health Sciences, University of CaliforniaDepartment of Cell and Tissue Biology, University of CaliforniaDepartment of Pathology, Stanford University Medical CenterInstitute for Computational Health Sciences, University of CaliforniaInstitute for Computational Health Sciences, University of CaliforniaDepartment of Pathology, University of CaliforniaDepartment of Cell and Tissue Biology, University of CaliforniaInstitute for Computational Health Sciences, University of CaliforniaInstitute for Computational Health Sciences, University of CaliforniaNormal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour tissue.https://doi.org/10.1038/s41467-017-01027-z
collection DOAJ
language English
format Article
sources DOAJ
author Dvir Aran
Roman Camarda
Justin Odegaard
Hyojung Paik
Boris Oskotsky
Gregor Krings
Andrei Goga
Marina Sirota
Atul J. Butte
spellingShingle Dvir Aran
Roman Camarda
Justin Odegaard
Hyojung Paik
Boris Oskotsky
Gregor Krings
Andrei Goga
Marina Sirota
Atul J. Butte
Comprehensive analysis of normal adjacent to tumor transcriptomes
Nature Communications
author_facet Dvir Aran
Roman Camarda
Justin Odegaard
Hyojung Paik
Boris Oskotsky
Gregor Krings
Andrei Goga
Marina Sirota
Atul J. Butte
author_sort Dvir Aran
title Comprehensive analysis of normal adjacent to tumor transcriptomes
title_short Comprehensive analysis of normal adjacent to tumor transcriptomes
title_full Comprehensive analysis of normal adjacent to tumor transcriptomes
title_fullStr Comprehensive analysis of normal adjacent to tumor transcriptomes
title_full_unstemmed Comprehensive analysis of normal adjacent to tumor transcriptomes
title_sort comprehensive analysis of normal adjacent to tumor transcriptomes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour tissue.
url https://doi.org/10.1038/s41467-017-01027-z
work_keys_str_mv AT dviraran comprehensiveanalysisofnormaladjacenttotumortranscriptomes
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AT justinodegaard comprehensiveanalysisofnormaladjacenttotumortranscriptomes
AT hyojungpaik comprehensiveanalysisofnormaladjacenttotumortranscriptomes
AT borisoskotsky comprehensiveanalysisofnormaladjacenttotumortranscriptomes
AT gregorkrings comprehensiveanalysisofnormaladjacenttotumortranscriptomes
AT andreigoga comprehensiveanalysisofnormaladjacenttotumortranscriptomes
AT marinasirota comprehensiveanalysisofnormaladjacenttotumortranscriptomes
AT atuljbutte comprehensiveanalysisofnormaladjacenttotumortranscriptomes
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