Comprehensive analysis of normal adjacent to tumor transcriptomes
Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour...
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Nature Publishing Group
2017-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-01027-z |
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doaj-92442fbf71dc46038ab5ef9c6bf555db2021-05-11T07:21:26ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-01027-zComprehensive analysis of normal adjacent to tumor transcriptomesDvir Aran0Roman Camarda1Justin Odegaard2Hyojung Paik3Boris Oskotsky4Gregor Krings5Andrei Goga6Marina Sirota7Atul J. Butte8Institute for Computational Health Sciences, University of CaliforniaDepartment of Cell and Tissue Biology, University of CaliforniaDepartment of Pathology, Stanford University Medical CenterInstitute for Computational Health Sciences, University of CaliforniaInstitute for Computational Health Sciences, University of CaliforniaDepartment of Pathology, University of CaliforniaDepartment of Cell and Tissue Biology, University of CaliforniaInstitute for Computational Health Sciences, University of CaliforniaInstitute for Computational Health Sciences, University of CaliforniaNormal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour tissue.https://doi.org/10.1038/s41467-017-01027-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dvir Aran Roman Camarda Justin Odegaard Hyojung Paik Boris Oskotsky Gregor Krings Andrei Goga Marina Sirota Atul J. Butte |
spellingShingle |
Dvir Aran Roman Camarda Justin Odegaard Hyojung Paik Boris Oskotsky Gregor Krings Andrei Goga Marina Sirota Atul J. Butte Comprehensive analysis of normal adjacent to tumor transcriptomes Nature Communications |
author_facet |
Dvir Aran Roman Camarda Justin Odegaard Hyojung Paik Boris Oskotsky Gregor Krings Andrei Goga Marina Sirota Atul J. Butte |
author_sort |
Dvir Aran |
title |
Comprehensive analysis of normal adjacent to tumor transcriptomes |
title_short |
Comprehensive analysis of normal adjacent to tumor transcriptomes |
title_full |
Comprehensive analysis of normal adjacent to tumor transcriptomes |
title_fullStr |
Comprehensive analysis of normal adjacent to tumor transcriptomes |
title_full_unstemmed |
Comprehensive analysis of normal adjacent to tumor transcriptomes |
title_sort |
comprehensive analysis of normal adjacent to tumor transcriptomes |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-10-01 |
description |
Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour tissue. |
url |
https://doi.org/10.1038/s41467-017-01027-z |
work_keys_str_mv |
AT dviraran comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT romancamarda comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT justinodegaard comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT hyojungpaik comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT borisoskotsky comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT gregorkrings comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT andreigoga comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT marinasirota comprehensiveanalysisofnormaladjacenttotumortranscriptomes AT atuljbutte comprehensiveanalysisofnormaladjacenttotumortranscriptomes |
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1721452369589305344 |