β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

YAP and mutant p53 crosstalk to regulate transcriptional processes in cancers. Here, the authors show that endothelin-1 mediated activation of β-arrestin interacts with YAP to recruit mutant p53 to the TEAD/YAP complex to promote metastasis and chemoresistance in ovarian cancer.

Bibliographic Details
Main Authors: Piera Tocci, Roberta Cianfrocca, Valeriana Di Castro, Laura Rosanò, Andrea Sacconi, Sara Donzelli, Silvia Bonfiglio, Gabriele Bucci, Enrico Vizza, Gabriella Ferrandina, Giovanni Scambia, Giovanni Tonon, Giovanni Blandino, Anna Bagnato
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11045-8

Internet

https://doi.org/10.1038/s41467-019-11045-8

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