Population genetic and biophysical evidences reveal that purifying selection shapes the genetic landscape of Plasmodium falciparum RH ligands in Chhattisgarh and West Bengal, India

Population genetic and biophysical evidences reveal that purifying selection shapes the genetic landscape of Plasmodium falciparum RH ligands in Chhattisgarh and West Bengal, India

Abstract Background Reticulocyte binding protein-like homologs (RHs) are currently being evaluated as anti-erythrocytic stage vaccine targets against Plasmodium falciparum malaria. Present study explores the possible evolutionary drivers shaping the genetic organization of Pfrhs in Indian parasite p...

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Bibliographic Details
Main Authors: Sharmistha Ghoshal, Pramita Chowdhury, Sanhita Ray, Mitashree Mitra, Sumana Datta Kanjilal, Srikanta Sen, Anjan Kr. Dasgupta, Sanghamitra Sengupta
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Malaria
PfRH
Polymorphism
Selection
Vaccine
Online Access:http://link.springer.com/article/10.1186/s12936-020-03433-z

Internet

http://link.springer.com/article/10.1186/s12936-020-03433-z

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