BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux

BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux

Impaired autophagy has been shown to play a critical role in experimental and human acute pancreatitis (AP). However, the mechanism for transcriptional regulation of autophagy remains largely unknown. In this study, we aim to explore the role of BRD4 (bromodomain-containing protein 4), a transcripti...

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Bibliographic Details
Main Authors: Shuangjun Shen, Bin Li, Juanjuan Dai, Zengkai Wu, Yan He, Li Wen, Xingpeng Wang, Guoyong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
BRD4
acute pancreatitis
autophagic flux
SIRT1
lysosomal degradation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00618/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00618/full

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