Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives

Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives

Indolone-N-oxides have antiplasmodial properties against Plasmodium falciparum at the erythrocytic stage, with IC50 values in the nanomolar range. The mechanism of action of indolone derivatives involves the production of free radicals, which follows their bioreduction by an unknown mechanism. In th...

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Bibliographic Details
Main Authors: Laure-Estelle Cassagnes, Nambinina Rakotoarivelo, Serena Sirigu, Pierre Pério, Ennaji Najahi, Léonard M. G. Chavas, Andrew Thompson, Régis Gayon, Gilles Ferry, Jean A. Boutin, Alexis Valentin, Karine Reybier, Françoise Nepveu
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
malaria
inhibitor
mechanism
human quinone reductase 2
indolones
Online Access:http://www.mdpi.com/1420-3049/22/2/210

Internet

http://www.mdpi.com/1420-3049/22/2/210

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