Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks

Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks

Acute myeloid leukaemia (AML) is a haematopoietic malignancy caused by a combination of genetic and epigenetic lesions. Activation of the oncoprotein FLT3 ITD (Fms‑like tyrosine kinase with internal tandem duplications) represents a key driver mutation in 25–30% of AML patients. FLT3 is a class III...

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Bibliographic Details
Main Authors: Isabel Bär, Volker Ast, Daria Meyer, Rainer König, Martina Rauner, Lorenz C. Hofbauer, Jörg P. Müller
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
acute myeloid leukaemia (AML)
FMS-like tyrosine kinase 3 (FLT3)
haematopoietic niche
haematopoiesis
bone remodelling
osteoclast (OC)
Online Access:https://www.mdpi.com/2073-4409/9/11/2443

Internet

https://www.mdpi.com/2073-4409/9/11/2443

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