RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease

RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease

Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the Huntingtin gene. As disease-modifying therapies for HD are being developed, peripheral blood cells may be used to indicate disease progression and to monit...

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Bibliographic Details
Main Authors: Miguel A. Andrade-Navarro, Katja Mühlenberg, Eike J. Spruth, Nancy Mah, Adrián González-López, Tommaso Andreani, Jenny Russ, Matthew R. Huska, Enrique M. Muro, Jean-Fred Fontaine, Vyacheslav Amstislavskiy, Alexei Soldatov, Wilfried Nietfeld, Erich E. Wanker, Josef Priller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neurology
Subjects:
RNA-Seq
differential gene expression
Huntington's disease
disease markers
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.573560/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2020.573560/full

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