Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation.

Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation.

By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes. In humans, the strand passage reaction of DNA topoisomerase II (Topo II) is the target of several major classes of cancer drugs which both po...

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Bibliographic Details
Main Authors: Katherine L Furniss, Hung-Ji Tsai, Jo Ann W Byl, Andrew B Lane, Amit C Vas, Wei-Shan Hsu, Neil Osheroff, Duncan J Clarke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3789831?pdf=render

Internet

http://europepmc.org/articles/PMC3789831?pdf=render

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