Mutational signature distribution varies with DNA replication timing and strand asymmetry

Mutational signature distribution varies with DNA replication timing and strand asymmetry

Abstract Background DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures—each representing a mutagenic process—derived from 3056 patients spanning 19 cancer types to quantify the st...

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Bibliographic Details
Main Authors: Marketa Tomkova, Jakub Tomek, Skirmantas Kriaucionis, Benjamin Schuster-Böckler
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Biology
Subjects:
Mutagenesis
DNA replication
DNA repair
Online Access:http://link.springer.com/article/10.1186/s13059-018-1509-y

Internet

http://link.springer.com/article/10.1186/s13059-018-1509-y

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