Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients

Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients

Influenza A virus (IAV) infection causes severe pulmonary disease characterized by intense leukocyte infiltration. Phosphoinositide-3 kinases (PI3Ks) are central signaling enzymes, involved in cell growth, survival, and migration. Class IB PI3K or phosphatidyl inositol 3 kinase-gamma (PI3Kγ), mainly...

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Bibliographic Details
Main Authors: Cristiana C. Garcia, Luciana P. Tavares, Ana Carolina F. Dias, Fernanda Kehdy, Lucia Elena Alvarado-Arnez, Celso M. Queiroz-Junior, Izabela Galvão, Braulio H. Lima, Aline R. Matos, Ana Paula F. Gonçalves, Frederico M. Soriani, Milton O. Moraes, João T. Marques, Marilda M. Siqueira, Alexandre M. V. Machado, Lirlândia P. Sousa, Remo C. Russo, Mauro M. Teixeira
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
neutrophils
CD8+ T cells
natural killer cells
type-I IFN
p38
disease severity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00975/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00975/full

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