VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Abstract Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data. We apply our method to dissect the regulation of estrogen receptor-alpha...

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Bibliographic Details
Main Authors: Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Genome Biology
Subjects:
Breast cancer
Network analysis
Dynamics
ER
Master regulator
ChIP-seq
Online Access:http://link.springer.com/article/10.1186/s13059-019-1698-z

Internet

http://link.springer.com/article/10.1186/s13059-019-1698-z

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