GFRα 1-2-3-4 co-receptors for RET Are co-expressed in Pituitary Stem Cells but Individually Retained in Some Adenopituitary Cells

GFRα 1-2-3-4 co-receptors for RET Are co-expressed in Pituitary Stem Cells but Individually Retained in Some Adenopituitary Cells

The RET tyrosine kinase receptor is expressed by the endocrine somatotroph cells of the pituitary where it has important functions regulating survival/apoptosis. However, RET is also expressed by the GPS pituitary stem cells localized in a niche between the adenopituitary and the intermediate lobe....

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Bibliographic Details
Main Authors: Alberto Pradilla Dieste, Miguel Chenlo, Sihara Perez-Romero, Ángela R. Garcia-Rendueles, Maria Suarez-Fariña, Montserrat Garcia-Lavandeira, Ignacio Bernabeu, José Manuel Cameselle-Teijeiro, Clara V. Alvarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Endocrinology
Subjects:
pituitary stem cell niche
GPS
RET
progenitors
cell turnover
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00631/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00631/full

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