Permeation through the cell membrane of a boron-based β-lactamase inhibitor.

Bacteria express beta-lactamases to counteract the beneficial action of antibiotics. Benzo[b]-thiophene-2-boronic acid (BZB) derivatives are β-lactamase inhibitors and, as such, promising compounds to be associated with β-lactam antibacterial therapies. The uncharged form of BZB, in particular, is s...

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Bibliographic Details
Main Authors: Manuela Minozzi, Gianluca Lattanzi, Roland Benz, Maria P Costi, Alberto Venturelli, Paolo Carloni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21858024/pdf/?tool=EBI