Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate <it>Leishmania major</it>

<p>Abstract</p> <p>Background</p> <p>The unusual heterodimeric leishmanial DNA topoisomerase IB consists of a large subunit containing the phylogenetically conserved "core" domain, and a small subunit harboring the C-terminal region with the characteristic tyr...

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Bibliographic Details
Main Authors: Reguera Rosa M, Pérez-Pertejo Yolanda, García-Estrada Carlos, Balaña-Fouce Rafael
Format: Article
Language:English
Published: BMC 2008-07-01
Series:BMC Microbiology
Online Access:http://www.biomedcentral.com/1471-2180/8/113