5-aza-2'-deoxycytidine leads to reduced embryo implantation and reduced expression of DNA methyltransferases and essential endometrial genes.

5-aza-2'-deoxycytidine leads to reduced embryo implantation and reduced expression of DNA methyltransferases and essential endometrial genes.

BACKGROUND: The DNA demethylating agent 5-aza-2'-deoxycytidine (5-aza-CdR) incorporates into DNA and decreases DNA methylation, sparking interest in its use as a potential therapeutic agent. We aimed to determine the effects of maternal 5-aza-CdR treatment on embryo implantation in the mouse an...

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Bibliographic Details
Main Authors: Yu-Bin Ding, Chun-Lan Long, Xue-Qing Liu, Xue-Mei Chen, Liang-Rui Guo, Yin-Yin Xia, Jun-Lin He, Ying-Xiong Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3460940?pdf=render

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http://europepmc.org/articles/PMC3460940?pdf=render

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