In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

Here, we present a method for in-depth human plasma proteome analysis based on high-resolution isoelectric focusing HiRIEF LC-MS/MS, demonstrating high proteome coverage, reproducibility and the potential for liquid biopsy protein profiling. By integrating genomic sequence information to the MS-base...

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Bibliographic Details
Main Authors: Maria Pernemalm, AnnSofi Sandberg, Yafeng Zhu, Jorrit Boekel, Davide Tamburro, Jochen M Schwenk, Albin Björk, Marie Wahren-Herlenius, Hanna Åmark, Claes-Göran Östenson, Magnus Westgren, Janne Lehtiö
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
proteogenomics
plasma
proteomics
mass spectrometry
biomarker discovery
Online Access:https://elifesciences.org/articles/41608

Internet

https://elifesciences.org/articles/41608

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