Identification of binding pockets in protein structures using a knowledge-based potential derived from local structural similarities

<p>Abstract</p> <p>Background</p> <p>The identification of ligand binding sites is a key task in the annotation of proteins with known structure but uncharacterized function. Here we describe a knowledge-based method exploiting the observation that unrelated binding sit...

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Bibliographic Details
Main Authors: Bianchi Valerio, Gherardini Pier Federico, Helmer-Citterich Manuela, Ausiello Gabriele
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Bioinformatics