The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats

The hydrogen sulfide donor, Lawesson's reagent, prevents alendronate-induced gastric damage in rats

Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson's reagent (3, 9, or 27 µmol/kg, po) once daily for 4 days. After 30 min, gastric damage was ind...

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Bibliographic Details
Main Authors: L.A.D. Nicolau, R.O. Silva, S.R.B. Damasceno, N.S. Carvalho, N.R.D. Costa, K.S. Aragao, A.L.R. Barbosa, P.M.G. Soares, M.H.L.P. Souza, J.V.R. Medeiros
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2013-08-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Alendronate
Lawesson's reagent
H2S donors
Gastric damage
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800708&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800708&lng=en&tlng=en

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