Modular Synthesis and Biological Investigation of 5-Hydroxymethyl Dibenzyl Butyrolactones and Related Lignans

Modular Synthesis and Biological Investigation of 5-Hydroxymethyl Dibenzyl Butyrolactones and Related Lignans

Dibenzyl butyrolactone lignans are well known for their excellent biological properties, particularly for their notable anti-proliferative activities. Herein we report a novel, efficient, convergent synthesis of dibenzyl butyrolactone lignans utilizing the acyl-Claisen rearrangement to stereoselecti...

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Bibliographic Details
Main Authors: Samuel J. Davidson, Lisa I. Pilkington, Nina C. Dempsey-Hibbert, Mohamed El-Mohtadi, Shiying Tang, Thomas Wainwright, Kathryn A. Whitehead, David Barker
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
lignans
dibenzyl butyrolactones
anti-proliferative
acyl-Claisen
stereoselective synthesis
Online Access:https://www.mdpi.com/1420-3049/23/12/3057

Internet

https://www.mdpi.com/1420-3049/23/12/3057

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