Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy

Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy

Abstract Background Biglycan is a proteoglycan found in the extracellular matrix. We have previously shown that biglycan is secreted from tumor endothelial cells and induces tumor angiogenesis and metastasis. However, the function of stroma biglycan in breast cancer is still unclear. Methods Biglyca...

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Bibliographic Details
Main Authors: Li Cong, Nako Maishi, Dorcas A. Annan, Marian F. Young, Hirofumi Morimoto, Masahiro Morimoto, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Breast Cancer Research
Subjects:
Tumor stroma
Angiogenesis
Biglycan
Tumor microenvironment
Breast cancer
Online Access:https://doi.org/10.1186/s13058-021-01423-w

Internet

https://doi.org/10.1186/s13058-021-01423-w

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