PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

Intramuscular accumulation of triacylglycerol, in the form of lipid droplets (LD), has gained widespread attention as a hallmark of metabolic disease and insulin resistance. Paradoxically, LDs also amass in muscles of highly trained endurance athletes who are exquisitely insulin sensitive. Understan...

Full description

Bibliographic Details
Main Authors: Timothy R. Koves, Lauren M. Sparks, J.P. Kovalik, Merrie Mosedale, Ramamani Arumugam, Karen L. DeBalsi, Karen Everingham, Leigh Thorne, Esther Phielix, Ruth C. Meex, C. Lawrence Kien, Matthijs K.C. Hesselink, Patrick Schrauwen, Deborah M. Muoio
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Journal of Lipid Research
Subjects:
skeletal muscle
athlete's paradox
mitochondria
fatty acid metabolism
insulin sensitivity
gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520428172

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520428172

Similar Items