Importance of genotyping of Thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy

Importance of genotyping of Thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy

INTRODUCTION Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyses the inactivation of mercaptopurine (MP) which is widely used in the treatment of acute lymphoblastic leukaemia (ALL) of childhood. Potentially fatal myelotoxicity may develop after standard doses of MP in TPMT deficient p...

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Bibliographic Details
Main Authors: Dokmanović Lidija, Janić Dragana, Krstovski Nada, Zukić Branka, Tošić Nataša, Pavlović Sonja
Format: Article
Language:English
Published: Serbian Medical Society 2008-01-01
Series:Srpski Arhiv za Celokupno Lekarstvo
Subjects:
thiopurine S-methyltransferase
pharmacogenetics
acute lymphoblastic leukaemia
children
Online Access:http://www.doiserbia.nb.rs/img/doi/0370-8179/2008/0370-81790812609D.pdf

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http://www.doiserbia.nb.rs/img/doi/0370-8179/2008/0370-81790812609D.pdf

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