Drug Delivery Systems for Hedgehog Inhibitors in the Treatment of SHH-Medulloblastoma

Drug Delivery Systems for Hedgehog Inhibitors in the Treatment of SHH-Medulloblastoma

Medulloblastoma (MB) is a highly aggressive pediatric tumor of the cerebellum. Hyperactivation of the Hedgehog (HH) pathway is observed in about 30% of all MB diagnoses, thereby bringing out its pharmacological blockade as a promising therapeutic strategy for the clinical management of this malignan...

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Bibliographic Details
Main Authors: Miriam Caimano, Ludovica Lospinoso Severini, Elena Loricchio, Paola Infante, Lucia Di Marcotullio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Chemistry
Subjects:
medulloblastoma
hedgehog signaling
SMO antagonists
GLI inhibitors
drug delivery
nanoparticles
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.688108/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.688108/full

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