DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer

by Francesca Bufalieri, Ludovica Lospinoso Severini, Miriam Caimano, Paola Infante, Lucia Di Marcotullio
Published 2020-06-01

Drug Delivery Systems for Hedgehog Inhibitors in the Treatment of SHH-Medulloblastoma

by Miriam Caimano, Ludovica Lospinoso Severini, Elena Loricchio, Paola Infante, Lucia Di Marcotullio, Lucia Di Marcotullio
Published 2021-06-01

The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I

by Francesca Bufalieri, Miriam Caimano, Ludovica Lospinoso Severini, Irene Basili, Francesco Paglia, Luigi Sampirisi, Elena Loricchio, Marialaura Petroni, Gianluca Canettieri, Antonio Santoro, Luca D’Angelo, Paola Infante, Lucia Di Marcotullio
Published 2020-01-01

A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth

by Ludovica Lospinoso Severini, Deborah Quaglio, Irene Basili, Francesca Ghirga, Francesca Bufalieri, Miriam Caimano, Silvia Balducci, Marta Moretti, Isabella Romeo, Elena Loricchio, Marella Maroder, Bruno Botta, Mattia Mori, Paola Infante, Lucia Di Marcotullio
Published 2019-10-01

A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

by Ana María Zárate, Christian Espinosa-Bustos, Simón Guerrero, Angélica Fierro, Felipe Oyarzún-Ampuero, Andrew F. G. Quest, Lucia Di Marcotullio, Elena Loricchio, Miriam Caimano, Andrea Calcaterra, Matías González-Quiroz, Adam Aguirre, Jaime Meléndez, Cristian O. Salas
Published 2021-08-01

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

by Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci, Lucia Di Marcotullio
Published 2019-07-01