Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors

Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors

Regulation of AMPA receptor expression by neuronal activity and neuromodulators is critical to the expression of both long-term potentiation (LTP) and memory. In particular, Ca2+-permeable AMPARs (CP-AMPAR) play a unique role in these processes due to their transient, activity-regulated expression a...

Full description

Bibliographic Details
Main Authors: Rhys W. Livingstone, Megan K. Elder, Anurag Singh, Courteney M. Westlake, Warren P. Tate, Wickliffe C. Abraham, Joanna M. Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
secreted amyloid precursor protein alpha
FUNCAT-PLA
long-term potentiation
Alzheimer’s disease
activity related cytoskeletal (Arc) associated protein
plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.660208/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.660208/full

Similar Items