ROR2 induces cell apoptosis via activating IRE1α/JNK/CHOP pathway in high-grade serous ovarian carcinoma in vitro and in vivo

ROR2 induces cell apoptosis via activating IRE1α/JNK/CHOP pathway in high-grade serous ovarian carcinoma in vitro and in vivo

Abstract Background Epithelial ovarian cancer (EOC) is the most lethal cancer in female genital tumors. New disease markers and novel therapeutic strategies are urgent to identify considering the current status of treatment. Receptor tyrosine kinases family plays critical roles in embryo development...

Full description

Bibliographic Details
Main Authors: Rui Li, Tianfeng Liu, Juanjuan Shi, Wenqing Luan, Xuan Wei, Jiangtao Yu, Hongluan Mao, Peishu Liu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Translational Medicine
Subjects:
ROR2
High-grade serous ovarian carcinoma
Apoptosis
IRE1α/JNK/CHOP pathway
Online Access:https://doi.org/10.1186/s12967-019-02178-x

Internet

https://doi.org/10.1186/s12967-019-02178-x

Similar Items