TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

Virus-specific CD8+T cells lose effector function over the course of chronic infection, a process called ‘exhaustion’, but the fate of these cells after treatment-induced antigen elimination is unknown. Here the authors show that exhausted cells persist in patients even after direct-acting antiviral...

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Main Authors: Dominik Wieland, Janine Kemming, Anita Schuch, Florian Emmerich, Percy Knolle, Christoph Neumann-Haefelin, Werner Held, Dietmar Zehn, Maike Hofmann, Robert Thimme
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15050
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spelling doaj-9297f10505a14ae8978a8c449887da652021-05-11T07:44:40ZengNature Publishing GroupNature Communications2041-17232017-05-018111310.1038/ncomms15050TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulationDominik Wieland0Janine Kemming1Anita Schuch2Florian Emmerich3Percy Knolle4Christoph Neumann-Haefelin5Werner Held6Dietmar Zehn7Maike Hofmann8Robert Thimme9Department of Medicine II, University Hospital Freiburg — Faculty of Medicine, University of FreiburgDepartment of Medicine II, University Hospital Freiburg — Faculty of Medicine, University of FreiburgDepartment of Medicine II, University Hospital Freiburg — Faculty of Medicine, University of FreiburgInstitute for Cell and Gene Therapy, University Hospital FreiburgInstitute of Molecular Immunology and Experimental Oncology, Technische Universität MünchenDepartment of Medicine II, University Hospital Freiburg — Faculty of Medicine, University of FreiburgDepartment of Fundamental Oncology, Ludwig Center for Cancer Research, University of LausanneDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University MunichDepartment of Medicine II, University Hospital Freiburg — Faculty of Medicine, University of FreiburgDepartment of Medicine II, University Hospital Freiburg — Faculty of Medicine, University of FreiburgVirus-specific CD8+T cells lose effector function over the course of chronic infection, a process called ‘exhaustion’, but the fate of these cells after treatment-induced antigen elimination is unknown. Here the authors show that exhausted cells persist in patients even after direct-acting antiviral therapy removes antigen exposure, and that these cells are responsive on re-exposure to antigen.https://doi.org/10.1038/ncomms15050
collection DOAJ
language English
format Article
sources DOAJ
author Dominik Wieland
Janine Kemming
Anita Schuch
Florian Emmerich
Percy Knolle
Christoph Neumann-Haefelin
Werner Held
Dietmar Zehn
Maike Hofmann
Robert Thimme
spellingShingle Dominik Wieland
Janine Kemming
Anita Schuch
Florian Emmerich
Percy Knolle
Christoph Neumann-Haefelin
Werner Held
Dietmar Zehn
Maike Hofmann
Robert Thimme
TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
Nature Communications
author_facet Dominik Wieland
Janine Kemming
Anita Schuch
Florian Emmerich
Percy Knolle
Christoph Neumann-Haefelin
Werner Held
Dietmar Zehn
Maike Hofmann
Robert Thimme
author_sort Dominik Wieland
title TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_short TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_full TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_fullStr TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_full_unstemmed TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_sort tcf1+ hepatitis c virus-specific cd8+ t cells are maintained after cessation of chronic antigen stimulation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Virus-specific CD8+T cells lose effector function over the course of chronic infection, a process called ‘exhaustion’, but the fate of these cells after treatment-induced antigen elimination is unknown. Here the authors show that exhausted cells persist in patients even after direct-acting antiviral therapy removes antigen exposure, and that these cells are responsive on re-exposure to antigen.
url https://doi.org/10.1038/ncomms15050
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