UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease

UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease

It is widely accepted that genetic polymorphisms impact atorvastatin (ATV) metabolism, clinical efficacy, and adverse events. The objectives of this study were to identify novel genetic variants influencing ATV metabolism and outcomes in Chinese patients with coronary artery disease (CAD). A total o...

Full description

Bibliographic Details
Main Authors: He-Ping Lei, Min Qin, Li-Yun Cai, Hong Wu, Lan Tang, Ju-E Liu, Chun-Yu Deng, Yi-Bin Liu, Qian Zhu, Han-Ping Li, Wei Hu, Min Yang, Yi-Zhun Zhu, Shi-Long Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
atorvastatin
coronary artery disease
UGT1A1∗6
polymorphisms
ADME genes
clinical outcomes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.586973/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.586973/full

Similar Items