Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation. Despite emergent evidence that TRPA1 is regulated by the membrane environment, it remains unknown whether this channel...

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Bibliographic Details
Main Authors: Justyna B Startek, Brett Boonen, Alejandro López-Requena, Ariel Talavera, Yeranddy A Alpizar, Debapriya Ghosh, Nele Van Ranst, Bernd Nilius, Thomas Voets, Karel Talavera
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
chemosensation
cholesterol
CRAC motif
lipid raft
TRPA1
sensory neuron
Online Access:https://elifesciences.org/articles/46084

Internet

https://elifesciences.org/articles/46084

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