Design and effective synthesis of novel furo[2,3-d]pyrimidine derivatives containing ethylene ether spacers

Design and effective synthesis of novel furo[2,3-d]pyrimidine derivatives containing ethylene ether spacers

[1+4] Cycloaddition reaction of ethylene ether-based N,N-dimethybenzylidenebarbituric acid with alkyl isocyanide in DMF produced novel high substituted furo[2,3-d]pyrimidine derivatives containing ether spacers under mild reaction conditions. The structures of the products were deduced from their IR...

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Bibliographic Details
Main Author: Enayatollah Sheikhhosseini
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Journal of Saudi Chemical Society
Subjects:
Alkyl isocyanide
Furo[2,3-d]pyrimidine
Ethylene ether spacer
Arylidenebarbituric acid
Antibacterial activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610316300382
Description
Summary:[1+4] Cycloaddition reaction of ethylene ether-based N,N-dimethybenzylidenebarbituric acid with alkyl isocyanide in DMF produced novel high substituted furo[2,3-d]pyrimidine derivatives containing ether spacers under mild reaction conditions. The structures of the products were deduced from their IR, 1H NMR, and 13C NMR spectroscopy. Good antibacterial activity was found in compound 5c.
ISSN:1319-6103

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