Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals. Coronavirus RNA synthesis is thought to be associated with replication organelles (ROs) consisting of modified endoplasmic reticulu...

Full description

Bibliographic Details
Main Authors: Diede Oudshoorn, Kevin Rijs, Ronald W. A. L. Limpens, Kevin Groen, Abraham J. Koster, Eric J. Snijder, Marjolein Kikkert, Montserrat Bárcena, Mark R. Denison
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/6/e01658-17

Internet

http://mbio.asm.org/cgi/content/full/8/6/e01658-17

Similar Items