The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis

The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis

The high mortality of OvCa is caused by the wide dissemination of cancer within the abdominal cavity. OvCa cells metastasize to the peritoneum, which is covered by mesothelial cells, and invade into the underlying stroma, composed of extracellular matrices (ECM) and stromal cells. In a study using a...

Full description

Bibliographic Details
Main Authors: Hilary A. Kenny, Peter C. Hart, Kasjusz Kordylewicz, Madhu Lal, Min Shen, Betul Kara, Yen-Ju Chen, Niklas Grassl, Yousef Alharbi, Bikash R. Pattnaik, Karen M. Watters, Manish S. Patankar, Marc Ferrer, Ernst Lengyel
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
β-escin
ovarian cancer
tumor microenvironment
metastasis
Digitoxin
Ouabain
Online Access:https://www.mdpi.com/2072-6694/13/16/3931

Internet

https://www.mdpi.com/2072-6694/13/16/3931

Similar Items