A Routine ‘Top-Down’ Approach to Analysis of the Human Serum Proteome

A Routine ‘Top-Down’ Approach to Analysis of the Human Serum Proteome

Serum provides a rich source of potential biomarker proteoforms. One of the major obstacles in analysing serum proteomes is detecting lower abundance proteins owing to the presence of hyper-abundant species (e.g., serum albumin and immunoglobulins). Although depletion methods have been used to addre...

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Bibliographic Details
Main Authors: Arlene M. D’Silva, Jon A. Hyett, Jens R. Coorssen
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Proteomes
Subjects:
deep Imaging
Lithium Dodecyl Sulfate
prefractionation
postfractionation
proteomics
proteoforms
three-dimensional gel electrophoresis
two-dimensional gel electrophoresis
Online Access:http://www.mdpi.com/2227-7382/5/2/13

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http://www.mdpi.com/2227-7382/5/2/13

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