Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes

Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes

Dedifferentiation has been implicated in β cell dysfunction and loss in rodent diabetes. However, the pathophysiological significance in humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese subjects with diabetes and 11 nondiabetic subjects, wh...

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Bibliographic Details
Main Authors: Kikuko Amo-Shiinoki, Katsuya Tanabe, Yoshinobu Hoshii, Hiroto Matsui, Risa Harano, Tatsuya Fukuda, Takato Takeuchi, Ryotaro Bouchi, Tokiyo Takagi, Masayuki Hatanaka, Komei Takeda, Shigeru Okuya, Wataru Nishimura, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Tetsuya Yamada, Yoshihiro Ogawa, Eiji Ikeda, Hiroaki Nagano, Yukio Tanizawa
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-01-01
Series:JCI Insight
Subjects:
Endocrinology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.143791

Internet

https://doi.org/10.1172/jci.insight.143791

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