Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy

Abstract Background Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules modulating myofibroblast differentiation a...

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Bibliographic Details
Main Authors: Paola Di Benedetto, Vasiliki Liakouli, Piero Ruscitti, Onorina Berardicurti, Francesco Carubbi, Noemi Panzera, Salvatore Di Bartolomeo, Giuliana Guggino, Francesco Ciccia, Giovanni Triolo, Paola Cipriani, Roberto Giacomelli
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
CD248
Fibrosis
Online Access:http://link.springer.com/article/10.1186/s13075-018-1719-4

Internet

http://link.springer.com/article/10.1186/s13075-018-1719-4

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