Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway

Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway

Secondary impairment of blood-brain barrier (BBB) occurs in the remote thalamus after ischemic stroke. Netrin-1, an axonal guidance molecule, presents bifunctional effects on blood vessels through receptor-dependent pathways. This study investigates whether netrin-1 protects BBB against secondary in...

Full description

Bibliographic Details
Main Authors: Jian Yu, Chenguang Li, Qiao Ding, Jiali Que, Kejia Liu, Haoyue Wang, Songjie Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Neuroscience
Subjects:
blood-brain barrier
ischemia
netrin-1
phosphatidylinositol 3 kinase
autophagy
thalamus
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00700/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00700/full

Similar Items