Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway

Secondary impairment of blood-brain barrier (BBB) occurs in the remote thalamus after ischemic stroke. Netrin-1, an axonal guidance molecule, presents bifunctional effects on blood vessels through receptor-dependent pathways. This study investigates whether netrin-1 protects BBB against secondary in...

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Bibliographic Details
Main Authors: Jian Yu, Chenguang Li, Qiao Ding, Jiali Que, Kejia Liu, Haoyue Wang, Songjie Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00700/full