Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

Pancreatic cancer is one of the most aggressive cancers whose prognosis is worsened by the poor response to the current chemotherapies. In this study, we investigated the cytotoxic effect of Apigenin, against two pancreatic cell lines, namely Panc1 and PaCa44, harboring different p53 mutations. Apig...

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Bibliographic Details
Main Authors: Maria Saveria Gilardini Montani, Nives Cecere, Marisa Granato, Maria Anele Romeo, Luca Falcinelli, Umberto Ciciarelli, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
apigenin
autophagy
catalase
HSP90
mutp53
NRF2
p62
pancreatic cancer
ROS
SOD
Online Access:https://www.mdpi.com/2072-6694/11/5/703

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https://www.mdpi.com/2072-6694/11/5/703

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