Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression

Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression

Background. Recent reports point to a nuclear origin of Alzheimer’s disease (AD). Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle. This aberrant cell cycle re-entry involves chromatin modifications where nuclear Tau and the nuclear lamin are involved. Th...

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Bibliographic Details
Main Authors: Laura Gil, Sandra A. Niño, Erika Chi-Ahumada, Ildelfonso Rodríguez-Leyva, Carmen Guerrero, Ana Belén Rebolledo, José A. Arias, María E. Jiménez-Capdeville
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
alzheimer’s disease
tau protein
lamin a
lamin b2
heterochromatin
cell-cycle
hippocampus
neurofibrillary tangles
Online Access:https://www.mdpi.com/1422-0067/21/5/1841

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https://www.mdpi.com/1422-0067/21/5/1841

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