Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders

Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental conditions categorized as synaptopathies. Environmental risk factors contribute to ASD aetiology. In particular, prenatal exposure to the anti-epileptic drug valproic acid (VPA) may increase the risk of autism. In the pr...

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Bibliographic Details
Main Authors: Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Grzegorz Arkadiusz Czapski, Henryk Jęśko, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Agnieszka Dominiak, Rafał Polowy, Robert Kuba Filipkowski, Lidia Babiec, Agata Adamczyk
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
synaptic ultrastructure
pre- and postsynaptic proteins
synaptopathology
oxidative stress
neuroinflammation
microglia
Online Access:https://www.mdpi.com/1422-0067/21/10/3576

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https://www.mdpi.com/1422-0067/21/10/3576

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