N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases

The normal cellular isoform of prion protein, designated PrP<sup>C</sup>, is constitutively converted to the abnormally folded, amyloidogenic isoform, PrP<sup>Sc</sup>, in prion diseases, which include Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform ence...

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Bibliographic Details
Main Authors: Hideyuki Hara, Suehiro Sakaguchi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/17/6233