Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation

Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation

Stem cells display a fundamentally different mechanism of proliferation control when compared to somatic cells. Uncovering these mechanisms would maximize the impact in drug discovery with a higher translational applicability. The unbiased approach used in phenotype-based drug discovery (PDD) progra...

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Bibliographic Details
Main Authors: Chang Yin, Temesgen Fufa, Gayathri Chandrasekar, Madhu Aeluri, Verina Zaky, Shaimaa Abdelhady, Antonio B. Rodríguez, Johan Jakobsson, Farzaneh Shahin Varnoosfaderani, Jayashri Mahalingam, Jianping Liu, Olle Larsson, Outi Hovatta, Frank Gaunitz, Anita Göndör, Michael Andäng, Satish S. Kitambi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
small molecules
stem cells
phenotype
zebrafish
mouse
PDD
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00726/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00726/full

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