Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles.

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles.

Abnormal protein aggregation within neurons is a key pathologic feature of Parkinson's disease (PD). The spread of brain protein aggregates is associated with clinical disease progression, but how this occurs remains unclear. Mutations in glucosidase, beta acid 1 (GBA), which encodes glucocereb...

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Bibliographic Details
Main Authors: Kathryn A Jewett, Ruth E Thomas, Chi Q Phan, Bernice Lin, Gillian Milstein, Selina Yu, Lisa F Bettcher, Fausto Carnevale Neto, Danijel Djukovic, Daniel Raftery, Leo J Pallanck, Marie Y Davis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008859

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https://doi.org/10.1371/journal.pgen.1008859

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