Autocrine Production of PDGF Stimulated by the Tenascin-C-Derived Peptide TNIIIA2 Induces Hyper-Proliferation in Glioblastoma Cells

Autocrine Production of PDGF Stimulated by the Tenascin-C-Derived Peptide TNIIIA2 Induces Hyper-Proliferation in Glioblastoma Cells

Expression level of tenascin-C is closely correlated to poor prognosis in glioblastoma patients, while the substantial role of tenascin-C responsible for aggressive progression in glioblastoma cells has not been clarified. We previously found that peptide TNIIIA2, which is derived from the tumor-ass...

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Bibliographic Details
Main Authors: Motomichi Fujita, Tetsuya Yamamoto, Takuya Iyoda, Tatsuya Fujisawa, Reo Nagai, Chikako Kudo, Manabu Sasada, Hiroaki Kodama, Fumio Fukai
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
tenascin-C
β1-integrin
glioblastoma
PDGF
PDGF receptor
Online Access:https://www.mdpi.com/1422-0067/20/13/3183

Internet

https://www.mdpi.com/1422-0067/20/13/3183

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