Apelin Affects the Progression of Osteoarthritis by Regulating VEGF-Dependent Angiogenesis and miR-150-5p Expression in Human Synovial Fibroblasts

Apelin Affects the Progression of Osteoarthritis by Regulating VEGF-Dependent Angiogenesis and miR-150-5p Expression in Human Synovial Fibroblasts

Synovium-induced angiogenesis is central to osteoarthritis (OA) pathogenesis and thus a promising therapeutic target. The adipokine apelin (APLN) is involved in both OA pathogenesis and angiogenesis. We examined the role of APLN in synovium-induced angiogenesis by investigating the crosstalk between...

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Bibliographic Details
Main Authors: Yu-Han Wang, Shu-Jui Kuo, Shan-Chi Liu, Shih-Wei Wang, Chun-Hao Tsai, Yi-Chin Fong, Chih-Hsin Tang
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
osteoarthritis
apelin
vegf
synovial fibroblast
angiogenesis
Online Access:https://www.mdpi.com/2073-4409/9/3/594

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https://www.mdpi.com/2073-4409/9/3/594

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